A major goal of our research focuses on finding better and safer treatments for cancer, particularly for those for which we have no or very limited treatment options. Our natural immune system protects us from growth of cancerous cells. Some of the most important innate cell types responsible for natural defense against cancer cells are the natural killer (NK) cell and gamma-delta T cells (γδ T cells). When cancer cells evade our innate cell-mediated destruction, the result is tumor formation. Established tumors can not only reduce NK cell and γδ T cell numbers but also significantly inhibit their function, further hindering the immune system’s ability to eliminate the tumor. Therefore, finding a method to increase the number and function of NK cells and/or γδ T cells in cancer patients could provide a safe and effective cancer treatment, particularly for solid tumors where limited treatment options are available.