SELECTED PUBLICATIONS

What Defines NK Cell Functional Fate: Phenotype or Metabolism?
Poznanski SM, Ashkar AA.
Front Immunol. 2019 Jun 19;10:1414. doi: 10.3389/fimmu.2019.01414.
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Type I Interferon Receptor on NK Cells Negatively Regulates Interferon-γ Production.
Lee AJ, Mian F, Poznanski SM, Stackaruk M, Chan T, Chew MV, Ashkar AA.
Front Immunol. 2019 Jun 4;10:1261. doi: 10.3389/fimmu.2019.01261.
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Thermal Stabilization of Viral Vaccines in Low-Cost Sugar Films.
Leung V, Mapletoft J, Zhang A, Lee A, Vahedi F, Chew M, Szewczyk A, Jahanshahi-Anbuhi S, Ang J, Cowbrough B, Miller MS, Ashkar A, Filipe CDM.
Sci Rep. 2019 May 21;9(1):7631. doi: 10.1038/s41598-019-44020-w.
News Feature: McMaster News & National Post
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Shining light on the significance of NK cell CD56 brightness.
Poznanski SM, Ashkar AA.
Cell Mol Immunol. 2018 Dec;15(12):1071-1073. doi: 10.1038/s41423-018-0163-3.
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The Dual Nature of Type I and Type II Interferons.
Lee AJ, Ashkar AA.
Front Immunol. 2018 Sep 11;9:2061. doi: 10.3389/fimmu.2018.02061. eCollection 2018.
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Immunometabolism of T cells and NK cells: metabolic control of effector and regulatory function.
Poznanski SM, Barra NG, Ashkar AA, Schertzer JD.
Inflamm Res. 2018 Oct;67(10):813-828. doi: 10.1007/s00011-018-1174-3.
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Poznanski SM, Nham T, Chew MV, Lee AJ, Hammill JA, Fan IY, Butcher M, Bramson JL, Lee DA, Hirte HW, Ashkar AA.
Cancer Immunol Res. 2018 Jul 17. doi: 10.1158/2326-6066.CIR-18-0144.
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Vahedi F, Lee AJ, Collins SE, Chew MV, Lusty E, Chen B, Dubey A, Richards CD, Feld JJ, Russell RS, Mossman KL, Ashkar AA.
Cytokine. 2018 Jun 13. pii: S1043-4666(18)30254-0. doi: 10.1016/j.cyto.2018.06.006.
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Barra NG, Fan IY, Gillen JB, Chew M, Marcinko K, Steinberg GR, Gibala MJ, Ashkar AA.
J Cancer Prev. 2017 Dec;22(4):260-266. doi: 10.15430/JCP.2017.22.4.260.
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Nham T, Poznanski SM, Fan IY, Shenouda MM, Chew MV, Lee AJ, Vahedi F, Karimi Y, Butcher M, Lee DA, Hirte H, Ashkar AA.
Cancer Immunol Immunother. 2018 Jan 3. doi: 10.1007/s00262-017-2112-x.
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Barra NG, Fan IY, Gillen JB, Chew M, Marcinko K, Steinberg GR, Gibala MJ, Ashkar AA.
J Cancer Prev. 2017 Dec;22(4):260-266. doi: 10.15430/JCP2017.22.4.260. Epub 2017 Dec 30.
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Nham T, Poznanski SM, Fan IY, Vahedi F, Shenouda MM, Lee AJ, Chew MV, Hogg RT, Lee DA, Ashkar AA.
J Immunother. 2017 Nov 17. doi: 10.1097/CJI.0000000000000192. [Epub ahead of print]
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Vahedi F, Nham T, Poznanski SM, Chew MV, Shenouda MM, Lee D, Ashkar AA.
Sci Rep. 2017 Sep 21;7(1): 12083. doi: 10.1038/s41598-017-12223-8.
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The Application of Humanized Mouse Models for the Study of Human Exclusive Viruses.
Vahedi F, Giles EC, Ashkar AA.
Methods Molec Biol. 2017; 1656: 1-56. doi: 10.1007/978-1-4939-7237-1_1.
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Shenouda MM, Gillgrass A, Nham T, Hogg R, Lee AJ, Chew MV, Shafaei M, Aarts C, Lee DA, Hassell J, Bane A, Dhesy-Thind S, Ashkar AA.
Breast Cancer Res. 2017 Jul 1;19(1):76. doi: 10.1186/s13058-017-0867-9.
PMID:28668076
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Lusty E, Poznanski SM, Kwofie K, Mandur TS, Lee DA, Richards CD, Ashkar AA.
Mol Immunol. 2017 Aug;88:138-147. doi: 10.1016/j.molimm.2017.06.025. Epub 2017 Jun 20.
PMID: 28644973
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Poznanski SM, Lee AJ, Nham T, Lusty E, Larché MJ, Lee DA, Ashkar AA.
J Innate Immun. 2017 Jun 21. doi: 10.1159/000477172. [Epub ahead of print]
PMID: 28633138
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Yao Y, Lai R, Afkhami S, Haddadi S, Zganiacz A, Vahedi F, Ashkar AA, Kaushic C, Jeyanathan M, Xing Z.
J Infect Dis. 2017 May 20. doi: 10.1093/infdis/jix252. [Epub ahead of print]
PMID: 28531291
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Lee AJ, Chen B, Chew MV, Barra NG, Shenouda MM, Nham T, Rooijen Nv, Jordana M, Mossman KL,
Schreiber RD, Mack M, Ashkar AA. J. Exp. Med. 2017 Mar 6;214(3). doi: 10.1084/jem.20160880.
PMID: 28264883
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Type I interferon signalling is not required for the induction of endotoxin tolerance.
Karimi Y, Poznanski S, Vahedi F, Chen B, Chew M, Lee A, Ashkar AA. Cytokine. 2017 Jul 31;95:7-11.
doi: 10.1016/j.cyto.2017.01.017.
PMID: 28189043
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He W, Tan GS, Mullarkey CE, Lee AJ, Lam MM, Krammer F, Henry C, Wilson PC, Ashkar AA,
Palese P, Miller MS. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11931-11936.
doi:10.1073/pnas.1609316113. Epub 2016 Oct 3.
PMID: 27698132
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Krneta T, Gillgrass A, Poznanski S, Chew M, Lee AJ, Kolb M, Ashkar AA. J Leukoc Biol.
doi:10.1189/jlb.3A1215-552R. Epub 2016 Aug 4.
PMID: 27493241
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Bulir D, Liang S, Lee A, Chong S, Simms E, Stone C, Kaushic C, Ashkar AA, Mahony J.
Vaccine. 2016 Jul 25; 34(34): 3979-3985. doi: 10.1016/j.vaccine.2016.06.046. Epub 2016 Jun 17.
PMID: 27325352
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Dykstra C, Lee AJ, Lusty EJ, Shenouda MM, Shafai M, Vahedi F, Chew MV, Collins S, Ashkar AA.
BMC Immunol. 2016 Jun 16;17(1):18. doi: 10.1186/s12865-016-0157-9.
PMID: 27307066
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S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.
Wang F, Alain T, Szretter KJ, Stephenson K, Pol JG, Atherton MJ, Hoang HD, Fonseca BD, Zakaria
C, Chen L, Rangwala Z, Hesch A, Chan ES, Tuinman C, Suthar MS, Jiang Z, Ashkar AA, Thomas
G, Kozma SC, Gale M Jr, Fitzgerald KA, Diamond MS, Mossman K, Sonenberg N, Wan Y,
Lichty BD.
Nat Immunol. 2016 May;17(5):514-22. doi: 10.1038/ni.3433. Epub 2016 Apr 4.
PMID: 27043414
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The breast tumor microenvironment alters the phenotype and function of natural killer cells.
Krneta T, Gillgrass A, Chew M, Ashkar AA. Cell Mol Immunol. 2015 Aug 17.
doi: 10.1038/cmi.2015.42. [Epub ahead of print]
PMID: 26277898
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Novel function of Oncostatin M as a potent tumour-promoting agent in lung.
Lauber S, Wong S, Cutz JC, Tanaka M, Barra N, Lhoták S, Ashkar A, Richards CD.
Int J Cancer. 2015 Feb 15;136(4):831-43. doi: 10.1002/ijc.29055. Epub 2014 Jul 7.
PMID: 24976180
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Vitamin D3 modulates the function of chicken macrophages.
Shojadoost B, Behboudi S, Villanueva Al, Brisbin JT, Ashkar AA, Sharif S.
Res Vet Sci. 2015 Jun; 100: 45-51. doi:10.1016/j.rvsc.2015.03.009. Epub 2015 Mar 9.
PMID: 25814176
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Type I IFN signaling on dendritic cells is required for NK cell-mediated anti-tumor immunity.
Karimi K, Karimi Y, Chan J, Boudreau JE, Basset J, Chew MV, Reid S, Bramson JL, Wan Y,
Ashkar AA.
Innate Immun. 2015 Mar 5. pii:1753425915575078. [Epub ahead of print]
PMID: 25749844
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Denou E, Lolmède K, Garidou L, Pomie C, Chabo C, Lau TC, Fullerton MD, Nigro G, Zakaroff-Girard
A, Luche E, Garret C, Serino M, Amar J, Courtney M, Cavallari JF, Henriksbo BD, Barra NG, Foley
KP, McPhee JB, Duggan BM, O'Neill HM, Lee AJ, Sansonetti P, Ashkar AA, Khan WI, Surette MG,
Bouloumié A, Steinberg GR, Burcelin R, Schertzer JD.
EMBO Mol Med. 2015 Feb 9. pii: e201404169. doi: 10.15252/emmm.201404169. [Epub ahead of print]
PMID: 25666722
Gillgrass A, Gill N, Babian A, Ashkar AA.
J Immunol. 2014 Dec 15:193(12):6184-91. doi: 10.4049/jimmunol. 1303175. Epub 2014 Oct 29
PMID: 25355926
Taylor KE, Chew MV, Ashkar AA, Mossman KL.
J Virol. 2014 May 7.
PMID: 24807717
Chu DK, Mohammed-Ali Z, Jiménez-Saiz R, Walker TD, Goncharova S, Llop-Guevara A, Kong J,
Gordon ME, Barra NG, Gillgrass AE, Van Seggelen H, Khan WI, Ashkar AA, Bramson JL,
Humbles AA, Kolbeck R, Waserman S, Jordana M.
Mucosal Immunol. 2014 Apr 30. doi: 10.1038/mi.2014.29.
PMID: 24781052
Lai R, Jeyanathan M, Shaler CR, Damjanovic D, Khera A, Horvath C, Ashkar AA, Xing Z.
Eur J Immunol. 2014 May;44(5):1375-86. doi: 10.1002/eji.201344300. Epub 2014 Apr 4.
PMID:24519467
Nazli A, Kafka JK, Ferreira VH, Anipindi V, Mueller K, Osborne BJ, Dizzell S, Chauvin S, Mian MF,
Ouellet M, Tremblay MJ, Mossman KL, Ashkar AA, Kovacs C, Bowdish DM, Snider DP, Kaul R,
Kaushic C.
J Immunol. 2013 Oct 15;191(8):4246-58. doi: 10.4049/jimmunol.1301482. Epub 2013 Sep 16.
PMID: 24043886
Type I interferon regulation of natural killer cell function in primary and secondary infections.
Stackaruk ML, Lee AJ, Ashkar AA.
Expert Rev Vaccines. 2013 Aug;12(8):875-84. doi: 10.1586/14760584.2013.814871. Review.
PMID: 23984959
Length of dsRNA (poly I:C) drives distinct innate immune responses, depending on the cell type.
Mian MF, Ahmed AN, Rad M, Babaian A, Bowdish D, Ashkar AA.
J Leukoc Biol. 2013 Aug 2. [Epub ahead of print]
PMID: 23911868
Interleukin-15 is required for maximal lipopolysaccharide-induced abortion.
Lee AJ, Kandiah N, Karimi K, Clark DA, Ashkar AA.
J Leukoc Biol. 2013 Jun;93(6):905-12. doi: 10.1189/jlb.0912442. Epub 2013 Mar 15.
PMID: 23505315
Immunity to ocular and genital herpes simplex viruses infections.
Chentoufi AA, BenMohamed L, Van De Perre P, Ashkar AA.
Clin Dev Immunol. 2012;2012:732546. doi: 10.1155/2012/732546. Epub 2012 Dec 26.
No abstract available.
PMID: 23326289
The influence of macrophages and the tumor microenvironment on natural killer cells.
Krneta T, Gillgrass A, Ashkar AA.
Curr Mol Med. 2013 Jan;13(1):68-79.
PMID: 22834841
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Interleukin-15 treatment induces weight loss independent of lymphocytes.
Barra NG, Chew MV, Reid S, Ashkar AA.
PLoS One. 2012;7(6):e39553. doi: 10.1371/journal.pone.0039553. Epub 2012 Jun 29.
PMID: 22768089
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Critical role of natural killer cells in lung immunopathology during influenza infection in mice.
Abdul-Careem MF, Mian MF, Yue G, Gillgrass A, Chenoweth MJ, Barra NG, Chew MV, Chan T,
Al-Garawi AA, Jordana M, Ashkar AA.
J Infect Dis. 2012 Jul 15;206(2):167-77. doi: 10.1093/infdis/jis340. Epub 2012 May 4.
PMID: 22561366
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Genital HSV-2 infection induces short-term NK cell memory.
Abdul-Careem MF, Lee AJ, Pek EA, Gill N, Gillgrass AE, Chew MV, Reid S, Ashkar AA.
PLoS One. 2012;7(3):e32821. doi: 10.1371/journal.pone.0032821. Epub 2012 Mar 22.
PMID: 22457721
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IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells.
Chenoweth MJ, Mian MF, Barra NG, Alain T, Sonenberg N, Bramson J, Lichty BD, Richards CD,
Ma A, Ashkar AA.
J Immunol. 2012 May 1;188(9):4149-57. doi: 10.4049/jimmunol.1101883. Epub 2012 Mar 23.
PMID: 22447977
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Mehta DR, Ashkar AA, Mossman KL.
PLoS One. 2012;7(2):e31688. doi: 10.1371/journal.pone.0031688. Epub 2012 Feb 21.
PMID: 22363706
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Regulation of pregnancy maintenance and fetal survival in mice by CD27(low) mature NK cells.
Karimi K, Solano ME, Ashkar AA, Ho H, Steidle EM, McVey Neufeld KA, Hecher K, Bienenstock
J, Arck PC.
J Mol Med (Berl). 2012 Sep;90(9):1047-57. doi: 10.1007/s00109-012-0872-5. Epub 2012 Feb 23.
PMID: 22358070
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Stephenson KB, Barra NG, Davies E, Ashkar AA, Lichty BD.
Cancer Gene Ther. 2012 Apr;19(4):238-46. doi: 10.1038/cgt.2011.81. Epub 2011 Dec 9.
PMID: 22158521
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Lee AJ, Ashkar AA.
Curr Opin Infect Dis. 2012 Feb;25(1):92-9. doi: 10.1097/QCO.0b013e32834e9a56. Review.
PMID: 22143115
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Abdul-Careem MF, Firoz Mian M, Gillgrass AE, Chenoweth MJ, Barra NG, Chan T, Al-Garawi AA,
Chew MV, Yue G, van Roojen N, Xing Z, Ashkar AA.
Antiviral Res. 2011 Nov;92(2):346-55. doi: 10.1016/j.antiviral.2011.09.004. Epub 2011 Sep 14.
PMID: 21945041
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Interleukin-15 treatment improves glucose homeostasis and insulin sensitivity in obese mice.
Barra NG, Chew MV, Holloway AC, Ashkar AA.
Diabetes Obes Metab. 2012 Feb;14(2):190-3. doi: 10.1111/j.1463-1326.2011.01495.x. Epub 2011
Oct 30.
PMID: 21906226
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Ferreira VH, Nazli A, Khan G, Mian MF, Ashkar AA, Gray-Owen S, Kaul R, Kaushic C.
J Infect Dis. 2011 Jul 15;204(2):299-308. doi: 10.1093/infdis/jir260.
PMID: 21673042
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Humanized mice for Salmonella typhi infection: new tools for an old problem.
Mian MF, Pek EA, Chenoweth MJ, Coombes BK, Ashkar AA.
Virulence. 2011 May-Jun;2(3):248-52. Epub 2011 May 1.
PMID: 21623167
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Stimulating natural killer cells to protect against cancer: recent developments.
Gillgrass A, Ashkar A.
Expert Rev Clin Immunol. 2011 May;7(3):367-82. doi: 10.1586/eci.10.102. Review.
PMID: 2159560
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NK cells require type I IFN receptor for antiviral responses during genital HSV-2 infection.
Gill N, Chenoweth MJ, Verdu EF, Ashkar AA.
Cell Immunol. 2011;269(1):29-37. doi: 10.1016/j.cellimm.2011.03.007. Epub 2011 Mar 12.
PMID: 21477795
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A critical role for IL-15 in TLR-mediated innate antiviral immunity against genital HSV-2 infection.
Thatte A, DeWitte-Orr SJ, Lichty B, Mossman KL, Ashkar AA.
Immunol Cell Biol. 2011 Aug;89(6):663-9. doi: 10.1038/icb.2011.7. Epub 2011 Feb 22.
PMID: 21339766
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Innate and adaptive immunity against herpes simplex virus type 2 in the genital mucosa.
Chan T, Barra NG, Lee AJ, Ashkar AA.
J Reprod Immunol. 2011 Mar;88(2):210-8. doi: 10.1016/j.jri.2011.01.001. Epub 2011 Feb 21. Review.
PMID: 21334750
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Boudreau JE, Stephenson KB, Wang F, Ashkar AA, Mossman KL, Lenz LL, Rosenthal KL,
Bramson JL, Lichty BD, Wan Y.
Cancer Res. 2011 Apr 1;71(7):2497-506. doi: 10.1158/0008-5472.CAN-10-3025. Epub 2011 Feb 9.
PMID: 21307131
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Induction of innate immune responses in the female genital tract: friend or foe of HIV-1 infection?
Firoz Mian M, Ashkar AA.
Am J Reprod Immunol. 2011 Mar;65(3):344-51. doi: 10.1111/j.1600-0897.2010.00945.x. Epub 2011
Jan 12. Review.
PMID: 21223417
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Humanized mice are susceptible to Salmonella typhi infection.
Firoz Mian M, Pek EA, Chenoweth MJ, Ashkar AA.
Cell Mol Immunol. 2011 Jan;8(1):83-7. doi: 10.1038/cmi.2010.52. Epub 2010 Nov 8.
PMID: 21200387
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CD4(+) T-cells are important in regulating macrophage polarization in C57BL/6 wild-type mice.
Chan T, Pek EA, Huth K, Ashkar AA.
Cell Immunol. 2011;266(2):180-6. doi: 10.1016/j.cellimm.2010.10.002. Epub 2010 Oct 30.
PMID: 21040907
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Barra NG, Gillgrass A, Ashkar AA.
Expert Rev Vaccines. 2010 Oct;9(10):1143-7. doi: 10.1586/erv.10.119.
PMID: 20923266












